PMOS is the most common hormonal disorder in women of reproductive age, affecting 5–12% of women globally (1 in 8 women worldwide). It is characterized by irregular cycles, elevated androgens (causing acne, hair thinning, or excess hair growth), and previously misattributed "polycystic" ovarian appearance on ultrasound — but its root cause is metabolic, not ovarian.
The primary driver in the majority of PMOS cases is insulin resistance. Elevated insulin stimulates the ovaries to produce excess testosterone, disrupting follicle maturation and ovulation. This creates the androgen excess that produces most of PMOS's symptoms. Inflammation is a co-driver: elevated hs-CRP and gut dysbiosis worsen insulin resistance and androgen production. Obesity amplifies the cycle, but lean PMOS (where insulin resistance is present without obesity) is common and frequently overlooked.
We target the metabolic root — insulin resistance — through nutrition (carbohydrate management, anti-inflammatory dietary pattern, and meal timing), exercise prescription (resistance training is highly effective for PMOS), and targeted supplementation (inositol, chromium, magnesium, omega-3, and vitamin D all have evidence in PMOS/PCOS management).
Improvement in cycle regularity, androgen-driven symptoms (acne, hair), insulin sensitivity, and body composition over the programme period. Progress is tracked against repeat hormonal and metabolic testing.
