Depression is characterised by persistent low mood, loss of interest, fatigue, disrupted sleep, poor concentration, and changes in appetite or weight. While psychological and social factors play a role, research consistently demonstrates significant biological contributors that are frequently unaddressed in standard care.
Serotonin, dopamine, and noradrenaline, the neurotransmitters most associated with mood regulation, require specific nutritional precursors and cofactors to be synthesised. Deficiencies in tryptophan, tyrosine, B6, B12, folate, zinc, magnesium, and omega-3 fatty acids all impair neurotransmitter production.
Systemic inflammation is increasingly recognised as a causal pathway in depression. Elevated cytokines (triggered by gut dysbiosis, poor diet, chronic stress, or infection) cross the blood-brain barrier and suppress serotonin synthesis while promoting neuroinflammation.
Additional drivers include: HPA axis dysregulation (cortisol dominance suppressing mood pathways), oestrogen and progesterone fluctuations (particularly in perimenopause), vitamin D deficiency (a pro-hormone affecting serotonin gene transcription), and disrupted gut-brain axis signalling.
We assess the biological landscape alongside psychological support via our psychology specialist. Our role is to identify and correct the physiological drivers that compound or perpetuate low mood, providing the biological foundation from which psychological intervention is more effective.
A structured biological intervention targeting identified drivers. AdeaHealth does not replace psychiatric or psychological care — we work alongside it. Clients often report improved energy, sleep, and motivation within 8–12 weeks as biological factors are addressed.
Clinical note: AdeaHealth does not diagnose or treat clinical depression. Clients with active depressive episodes or suicidal ideation are referred to appropriate clinical and psychiatric services. Our role is biological optimisation in support of comprehensive care.
