High Cholesterol & Cardiovascular Risk.

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<span class="f-neue-bold">High Cholesterol</span> & <span class="f-neue-bold">Cardiovascular Risk</span>

What is it.

Cardiovascular disease remains the leading cause of death globally. Cholesterol is a key risk factor, but the standard NHS panel (total cholesterol, LDL, HDL, triglycerides) provides only a partial view. The particles that carry LDL — particularly small, dense LDL and elevated ApoB — are the true atherogenic drivers.

Why does it happen.

LDL particles become atherogenic when they are small and dense (produced in insulin-resistant states), oxidised (driven by inflammation and poor diet), or present in excess (ApoB elevation). Lipoprotein(a) is a genetically determined lipid particle with independently high cardiovascular risk — rarely measured in standard care. Triglycerides and the TG/HDL ratio reflect insulin resistance and metabolic risk. Homocysteine damages endothelial cells. ADMA/SDMA indicate endothelial dysfunction.

How AdeaHealth helps.

We run the full cardiovascular biomarker panel — going beyond total cholesterol to ApoB, Lp(a), particle size, the Omega-3 Index, and endothelial function markers. The programme addresses diet (seed oil reduction, anti-inflammatory pattern), omega-3 status, metabolic health, and lifestyle factors.

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What we test and measure.

  • ApoB: total atherogenic particle load — more predictive than LDL-C alone
  • Lipoprotein(a) [Lp(a)]: genetically determined; independently doubles cardiovascular risk
  • LDL-P & small LDL-P: particle number and size via NMR fractionation
  • TG/HDL molar ratio: insulin resistance and cardiovascular risk
  • Atherogenic Index of Plasma (AIP): composite cardiovascular risk
  • Omega-3 Index: EPA + DHA; <4% associated with high cardiovascular risk
  • Homocysteine: endothelial damage; target <10 µmol/L
  • hs-CRP: vascular inflammation
  • ADMA & SDMA: endothelial function
  • CT Coronary Angiography: structural arterial assessment (Longevity+)

What you can expect.

A complete cardiovascular risk picture — not a partial snapshot. Intervention targets identified drivers, and progress is tracked against repeat biomarker testing where requested. Clients with clinically elevated Lp(a) or ApoB are referred to our endocrinology partner.

Other conditions we address.

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