What Is Hashimoto’s Thyroiditis?

Hashimoto’s Thyroiditis is an autoimmune condition that affects the thyroid gland by producing antibodies that attack its cells, resulting in an enlarged, inflamed, and underactive thyroid. The thyroid gland, shaped like a butterfly and located at the front of the neck, is responsible for producing and secreting thyroid hormones known as triiodothyronine (T3) and thyroxine (T4), as well as the hormone calcitonin, which regulates calcium levels in the body. These hormones also help to regulate metabolism, body temperature, and energy levels. Hashimoto’s thyroiditis is also referred to as Hashimoto’s disease.

This condition is more common in women than in men, typically affecting those between the ages of 30 and 50 years. Individuals are at higher risk of developing Hashimoto’s if they have a family history of the condition or other autoimmune disorders, such as lupus, rheumatoid arthritis, or type 1 diabetes.

 

Understanding Hashimoto’s

 

Hashimoto’s is caused by an immune reaction often triggered by infection, environmental factors, or genetic predisposition. This reaction causes the immune system to send antibodies to attack the thyroid cells. As a result, the thyroid becomes underactive, a condition known as hypothyroidism, leading to insufficient production of thyroid hormones.

Hashimoto’s also causes the thyroid to become enlarged (goitre) and inflamed. In an attempt to compensate for low hormone levels, the thyroid increases in size as it tries to produce more thyroid hormones, resulting in an underactive and enlarged gland.

 

Symptoms

 

There are several symptoms to look out for with Hashimoto’s. One of the first signs is an enlarged thyroid gland, which usually isn’t painful but can make the neck appear swollen. Hashimoto’s leads to hypothyroidism, which is associated with symptoms such as weight gain, cold and dry skin, constipation, low heart rate, muscle cramps, fatigue, and carpal tunnel syndrome.

 

Diagnosis

 

A formal and conclusive diagnosis can only be made by a medical professional, such as a general practitioner or an endocrinologist. The doctor will typically ask about symptoms and family history. It’s important to be prepared with a list of medications, symptoms, and family history before visiting the doctor to ensure that all relevant information is provided for a correct diagnosis and suitable treatment plan.

After asking questions, the doctor may perform a physical examination, checking vital signs such as blood pressure and sugar levels and examining the neck for signs of an enlarged thyroid. A blood sample may also be taken and sent to a laboratory for analysis. The blood test will measure thyroid-stimulating hormone (TSH) and the levels of T3 and T4.

TSH is secreted by the pituitary gland in the brain and stimulates the thyroid to produce T3 and T4. If TSH levels are above the normal range and T4 levels are below the normal range, this indicates hypothyroidism.

The doctor may also conduct a thyroid antibody test, which checks for various antibodies that affect the thyroid. Two markers indicating Hashimoto’s are elevated levels of thyroid peroxidase antibodies and thyroglobulin antibodies. If the diagnosis is confirmed, it’s important to discuss possible treatment options with the doctor to ensure a normal quality of life.

 

Treatment Options

 

In most cases where Hashimoto’s leads to hypothyroidism, the first-line treatment is to replenish low T4 levels in the body via an oral medication called levothyroxine. This medication is absorbed and converted into T3, the more active thyroid hormone, which helps improve metabolism, alleviate constipation, and restore normal body temperature.

It’s essential for healthcare providers to schedule follow-up consultations to monitor thyroid hormone levels and ensure that the levothyroxine dose remains appropriate for the thyroid’s current level of function. In some cases, individuals with Hashimoto’s may not develop hypothyroidism. If this is the case, medication may not be necessary, but it is still important to regularly monitor thyroid function in case of changes.

Awareness of this condition is crucial, as long-term untreated hypothyroidism can lead to a life-threatening crisis known as myxoedema coma. This condition is characterised by severe hypothermia, hypotension, a slow respiratory rate, adrenal insufficiency, cold extremities, brittle nails, confusion, or coma. In such cases, treatment with both T3 and T4, along with glucocorticoids, is recommended, as the adrenal glands may not be functioning properly or producing enough cortisol for normal bodily functions.

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AdeaHealth Writing
Team.
Dr. Suzaan Jansen

BDS University of Western Cape; Dentist

Dané Kleynhnas

Bachelor of Pharmacy (B. Pharm & PCDT)

Cosette Greyling

Bachelor of Pharmacy
(BPharm & MPharm)

Salomé Jacobs

B.Pharm

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